DMG or TMG?
Dimethylglycine or DMG and TMG or trimethylglcine are frequently confused for each other as they share very similar chemical structures. TMG or trimethylglcine has three methyl groups attached to the glycine molecule, while DMG only has 2.
Both DMG and TMG are methyl donors. Like other methyl donors, such as SAM-e, DMAE, folic acid and B12, they are needed in the production of neurotransmitters (brain chemicals), which influence mood, energy, alertness, concentration, and visual clarity.
DMG and TMG, despite their similarities, perform very different functions in the body. TMG is involved in the methylation of homocysteine to form methionine. It is involved in the synthesis of many important bioactive substances, such as choline, SAM-e, the amino acid methionine, several hormones, neurotransmitters, and DNA.
Dimethylglycine or DMG is also known as Vitamin B15 or Pangamic Acid. It is a derivative of the amino acid, glycine. DMG is produced during the processing of phosphatidylcholine. The choline molecule is first converted to TMG, which then donate one of its methyl groups to homocysteine to form DMG. The DMG is then metabolized to sarcosine, and eventually glycine, which is a component of glutathione GSH (body’s Detox SuperStar). Glycine also functions as an important inhibitory neurotransmitter of the central nervous system.
DMG is more frequently recommended in children with autism. A study from Taiwan showed significant improvement in sleep quality, social interaction, eye contact, and verbal communication in children with autism supplemented with DMG.
However, DMG is more known for its stress reduction benefit and athletic performance improvement. It reduces stress by stimulating the body’s detoxification system. It enhances athletic performance by increasing oxygen uptake by muscle, reducing lactic acid buildup during activities and facilitate muscle recovery.
Dimethylglycine and ADHD – How Does DMG Help?
DMG improves ADHD symptoms by stimulating the liver’s detoxification system and acts as antioxidant to reduce oxidative and metabolic stresses, which have been suggested to be associated with certain behaviors and symptoms of ADHD and/or autism.
DMG also plays a significant role in the production of neurotransmitter in the brain, which promotes memory and mental clarity. DMG enhances the body’s immune system by stimulating B-cells to produce higher antibody responses and to potentiate a greater activity of T-cells and macrophages.
It is suspected that children with ADHD and/or autism may have an abnormal or suboptimal immune system, which may result in decreased number of helper T-cells and B-cells, reduced natural killer cell activity, inhibition of macrophage activity and increased interferon levels. DMG may potentially correct some of these defects of the immune system and, hence, improvement of ADHD and/or autism symptoms.
How Much DMG?
As you can see in the discussion here, DMG is naturally made in our body. Small amount of DMG may be found in food, such as grains, liver and beans.
According to Dr. Bernard Rimland in his Autism Research Review, he recommends a dose of 125mg DMG once to four times per day depending on age of the child.
· Vitamin E· Zinc Sulfate
· Dimethylglycine (DMG)
· Vitamin C
· Vitamin A
· Vitamin C
· Vitamin D
· Vitamin E